PRRS virus and TLRs:
Toll-like receptors (TLRs) play a crucial role in innate immunity as one of the pattern-recognition receptors directed against conserved molecules in pathogens.
TLR3, 7/8 and 9 in particular are involved in antiviral responses. Preliminary in vitro and in vivo results show that PRRS virus may produce interference or a transient inhibition of some of these TLRs in macrophages and DCs.
As a consequence, poor production of several cytokines may occur.