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This study was conducted to test the efficacy of UNISTRAIN® PRRS when administered intramuscularly or intradermally in pigs against a challenge with a PRRSV2 and a challenge with co-infection with PRRSV2 and PRRSV1.
Ruangurai Kitchodok et al.; Asian Pig Veterinary Society Congress, 2019
Under PRRSV2 field infection in 4 Thai farms, piglets vaccinated with UNISTRAIN® PRRS showed a significant improvement in productivity compared with the unsuccessful outcome achieved with the previous PRRSV2 vaccine.
Categories: Field experiences, Heterologous protection
This study confirms that UNISTRAIN® PRRS vaccine could effectively control reproductive failures induced by PRRSV through increased ratio of live born to total born piglets and decreased mortality rate of suckling piglets.
Genetic/antigenic diversity and variability in the immunobiological properties of the PRRSV (3,4) may compromise the heterologous protection generated by vaccination in PRRS control strategies. Although PRRS immunity is not yet fully understood, the significance not only of the NA but the cell-mediated immunity is important for a better understanding of vaccine performance (3). The present study showed that primo-immunization of naïve gilts with UNISTRAIN® PRRS induced a significant specific cell-mediated immunity against 5 heterologous PRRSV strains.